Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gm haplotypes in inflammatory demyelinating polyneuropathies.

D J Feeney1, J D Pollard, J G McLeod

  • 1Department of Medicine, University of Sydney, NSW, Australia.

Annals of Neurology
|December 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conduction block in immune-mediated neuropathy: paranodopathy versus axonopathy.

European journal of neurology·2019
Same author

Autoantibody responses to nodal and paranodal antigens in chronic inflammatory neuropathies.

Journal of neuroimmunology·2017
Same author

Data characterizing the ZMIZ1 molecular phenotype of multiple sclerosis.

Data in brief·2017
Same author

The autoimmune risk gene ZMIZ1 is a vitamin D responsive marker of a molecular phenotype of multiple sclerosis.

Journal of autoimmunity·2017
Same author

IFNL3/4 genotype is associated with altered immune cell populations in peripheral blood in chronic hepatitis C infection.

Genes and immunity·2016
Same author

Cistromic and genetic evidence that the vitamin D receptor mediates susceptibility to latitude-dependent autoimmune diseases.

Genes and immunity·2016
Same journal

Sex Differences in the Association of Simultaneous Decline in Blood Pressure and Decline in Cognition during Aging.

Annals of neurology·2026
Same journal

Neurophysiological Recovery Following Nerve Transfer Surgery to Restore Upper Limb Function after Cervical Spinal Cord Injury.

Annals of neurology·2026
Same journal

A new Patient-Reported Outcome Scale to assess autoimmune Encephalitis: PROSE.

Annals of neurology·2026
Same journal

Assessing Progression Independent of Relapse Activity in Multiple Sclerosis Using a Patient-Reported Disability Measure and Self-Administered Neuroperformance Outcomes.

Annals of neurology·2026
Same journal

AQP4 and MOG Characterize the Autoantibody Landscape of Checkpoint Blockade-Induced Optic Neuritis.

Annals of neurology·2026
Same journal

Five Issues of Artificial Intelligence in Science: Sailing the Ship of Theseus.

Annals of neurology·2026
See all related articles

Certain Gm haplotypes are linked to inflammatory neuropathies. The study found a specific Gm haplotype (1,2,17;21 or z,a,x;g) was more common in Guillain-Barré syndrome patients, suggesting a genetic link.

Area of Science:

  • Immunogenetics
  • Neurology
  • Human Genetics

Background:

  • Inflammatory neuropathies, such as Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy, are debilitating neurological disorders.
  • The genetic factors influencing susceptibility to these conditions are not fully understood.
  • Gm haplotypes, inherited variations in immunoglobulin heavy chain genes, are known to be associated with various immune-related conditions.

Purpose of the Study:

  • To investigate the potential association between specific Gm haplotypes and the development of inflammatory neuropathies.
  • To determine if Gm haplotype frequencies differ between patients with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) compared to healthy controls (though controls not explicitly mentioned, implied for frequency comparison).

Related Experiment Videos

Main Methods:

  • Case-control study design involving patients diagnosed with Guillain-Barré syndrome (n=59) and chronic inflammatory demyelinating polyradiculoneuropathy (n=55).
  • Analysis of Gm haplotype frequencies within the patient cohorts.
  • Statistical comparison of haplotype frequencies to identify significant associations.

Main Results:

  • A significantly higher frequency of Gm haplotype 1,2,17;21 (also denoted as z,a,x;g) was observed in patients diagnosed with Guillain-Barré syndrome.
  • This specific haplotype was found to be more prevalent in the GBS cohort, indicating a potential genetic predisposition.

Conclusions:

  • The findings suggest a significant association between Gm haplotype 1,2,17;21 (z,a,x;g) and Guillain-Barré syndrome.
  • These results provide further evidence supporting the role of genes on chromosome 14, specifically those related to immunoglobulin allotypes, in the pathogenesis of inflammatory neuropathies.