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Macular Hole Progression following Ocriplasmin Intravitreal Injection
Edward Casswell1, Guillermo Fernandez-Sanz2, Danny Mitry2
1Department of Ophthalmology, Western Eye Hospital, London NW1 5QH, UK ; Moorfields Eye Hospital, London EC1V 2PD, UK.
Abstract:
Ocriplasmin is a protease which has been approved for the treatment of symptomatic vitreomacular adhesion (VMA). A 63-year-old presented with blurred vision in the left eye and a best corrected visual acuity of 6/18. Optical coherence tomography revealed VMA with an underlying macular hole and she subsequently underwent a left intravitreal ocriplasmin injection. One week after the injection, VMA had been released but with enlargement of the macular hole and a drop in her BCVA to 6/60. This persisted at 1 month after the injection. It is important to warn patients that ocriplasmin may lead to an enlargement of their macular hole with resultant loss in visual acuity.
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