Photoactivable platforms for nitric oxide delivery with fluorescence imaging

Area of Science:

• Chemistry
• Biomedical Engineering
• Photochemistry

Background:

• Nitric oxide (NO) has critical physiological and pathological roles, driving interest in NO-releasing therapeutics.
• Controlling NO release spatiotemporally is challenging but crucial due to its site- and dose-dependent effects.

Purpose of the Study:

• To review recent advances in photoactivable platforms combining NO release with fluorescence.
• To highlight systems with persistent and photoactivable fluorescence for image-guided NO delivery.

Main Methods:

• Development and characterization of NO photodonors integrated with fluorescent moieties.
• Investigation of light-triggered NO release and fluorescence properties in biological contexts.

Main Results:

• Successful design of platforms enabling precise spatiotemporal NO release via light activation.
• Demonstration of combined NO photodonors and fluorescent functionalities for tracking and quantification.
• Systems exhibiting both persistent and photoactivable fluorescence signals were highlighted.

Conclusions:

• Photoactivable NO-releasing platforms with fluorescence offer precise control for NO delivery.
• These systems are promising for image-guided phototherapy and theranostics.
• Further development holds potential for advanced non-invasive therapeutic strategies.