Related Experiment Video
Updated: Apr 18, 2026
06:19
Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
Published on: May 16, 2025
2.4K
Management of severe ulcerative colitis.
Neeraj Narula1, Bindia Jharap, Jean-Frederic Colombel
1Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1069, New York, NY, 10029, USA.
Current Treatment Options in Gastroenterology
|January 18, 2015
Summary
Acute severe steroid-refractory ulcerative colitis (ASUC) management requires prompt inpatient care. Escalation to infliximab, cyclosporine, or colectomy is necessary if corticosteroids fail within three days.
Area of Science:
- Gastroenterology and Hepatology
- Colorectal Surgery
Background:
- Acute severe steroid-refractory ulcerative colitis (ASUC) presents significant clinical challenges.
- Effective management necessitates a multidisciplinary approach involving physicians and surgeons.
Purpose of the Study:
- To review the management strategies for ASUC.
- To focus on the available medical rescue therapy options.
Main Methods:
- Inpatient management protocols for ASUC.
- Intravenous corticosteroid administration.
- Exclusion of infections like Clostridium difficile.
Main Results:
- Failure to respond to corticosteroids by day 3 indicates a need for escalated treatment.
- Medical rescue therapies include infliximab and cyclosporine.
- Surgical intervention with colectomy is an alternative.
Conclusions:
- Prompt diagnosis and inpatient management are crucial for ASUC.
- Timely escalation to advanced therapies or surgery improves patient outcomes.
More Related Videos
Related Concept Videos
01:21Inflammatory Bowel Disease V: Surgical Management
905
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
905
01:29Drugs for Treatment of Ulcerative Colitis in IBD
675
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
675
01:29Inflammatory Bowel Disease IV: Pharmacological Management
1.0K
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
1.0K
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
686
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
686
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
1.1K
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.1K
01:26Peptic Ulcer Disease IV: Management
705
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
705