Related Experiment Video
Updated: Apr 18, 2026

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
Published on: March 8, 2013
Current status of optical imaging for evaluating lymph nodes and lymphatic system
Eun Seong Lee1, Tae Sung Kim1, Seok-Ki Kim1
1Department of Nuclear Medicine, Research Institute and Hospital, National Cancer Center, Goyang 410-769, Korea.
Optical imaging uses safe, intuitive visual and near-infrared rays for lymphatic system visualization. This review covers current and emerging optical tracers and techniques for lymph node imaging and clinical applications.
Area of Science:
- Medical Imaging
- Biophotonics
- Lymphatic System Research
Background:
- Optical imaging techniques, utilizing visual and near-infrared light, offer safe and intuitive methods for medical diagnostics.
- Despite limited penetration depth, these techniques are valuable for intraoperative guidance.
- The lymphatic system and lymph nodes are critical for disease detection and treatment, making them key targets for advanced imaging.
Purpose of the Study:
- To provide a comprehensive overview of optical tracers and techniques for lymph node and lymphatic imaging.
- To review the current clinical applications of these optical imaging modalities.
- To explore emerging optical imaging technologies and their future potential in this field.
Main Methods:
- Literature review of optical imaging techniques and tracers.
- Analysis of current clinical applications in lymph node and lymphatic imaging.
- Discussion of novel and emerging optical imaging technologies.
Main Results:
- A variety of optical tracers and techniques are employed for lymph node and lymphatic imaging.
- Existing optical imaging methods have demonstrated clinical utility.
- New optical imaging techniques are under development with promising potential.
Conclusions:
- Optical imaging is a valuable tool for visualizing the lymphatic system and lymph nodes.
- Continued development of optical tracers and techniques will enhance clinical applications.
- Emerging technologies promise to expand the capabilities of optical imaging in lymphatic diagnostics.
Related Concept Videos
Detailed Structure and Function of Lymph Nodes
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Lymphatic Vessels and Lymph Transport
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
Development of the Lymphatic System
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Functions of the Lymphatic and Immune System
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
Introduction to Lymphatic and Immune System
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
Secondary Lymphoid Organs
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

