Related Experiment Video

Updated: Apr 18, 2026

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
10:25

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

12.4K

Hepatitis B virus infection in patients with blood disorders: a concise review in pediatric study

N Mansouri, A Movafagh, A Sayad

  • 1;

Iranian Journal of Pediatric Hematology and Oncology
|January 20, 2015
PubMed

Insights

Childhood Hepatitis B virus (HBV) infection poses significant health risks, with infants facing a high chance of chronic infection. This study highlights the link between viral infections like HBV and HCV and various cancers, particularly leukemia.

Area of Science:

  • Hepatology
  • Oncology
  • Infectious Diseases

Background:

  • Childhood Hepatitis B virus (HBV) infection presents substantial medical and public health challenges.
  • Infants infected perinatally have a high risk (up to 90%) of developing chronic HBV infection.
  • Viral infections contribute to approximately 10% of global cancers, predominantly in developing nations.

Purpose of the Study:

  • To investigate the prevalence of Hepatitis B virus (HBV) and Hepatitis C virus (HCV) markers in patients with malignancies.
  • To explore the association between hepatitis viral infections and leukemia.

Main Methods:

  • A comprehensive web-based literature review was conducted.
  • Searched databases included Iran Medex, MEDLINE/PubMed, and CINAHL.
  • Included Persian and English peer-reviewed articles on HBV, HCV, and blood disorders in malignancies.

Main Results:

  • A high prevalence of HBV and HCV infective markers was observed in patients with various malignancies.
  • Elevated rates of HBV markers were noted in cancer patients compared to the general population.
  • A significant prevalence of HBV markers in leukemia patients suggests a strong association with hepatitis viral infections.

Conclusions:

  • Hepatitis B and C viral infections are prevalent in patients with malignancies.
  • There is a strong association between hepatitis viral infections and leukemia.
  • Further research is warranted to elucidate the mechanisms underlying these associations.

Keywords:
HBVHCVHeterogeneous populationMalignancyPediatric

More Related Videos

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle09:35

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

14.1K
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

8.0K

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
63
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
391
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
1
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
266
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
16.2K