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Updated: Apr 18, 2026

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Can tocilizumab decrease cartilage oligomeric matrix protein levels and disease activity in patients with

Maurizio Benucci, Francesca Meacci, Mariangela Manfredi

  • 1Rheumatology Unit, Azienda Sanitaria di Firenze, Hospital S. Giovanni di Dio, Via Torregalli 3, 50143 Firenze FI, Italy. maubenucci@tiscali.it.

Current Rheumatology Reviews
|January 21, 2015
PubMed
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Tocilizumab (TCZ) significantly reduced inflammation markers and disease activity in rheumatoid arthritis (RA) patients. While TCZ decreased serum cartilage oligomeric matrix protein (COMP) levels, this effect was not statistically significant over six months.

Area of Science:

  • Rheumatology
  • Immunology
  • Pharmacology

Background:

  • Serum cartilage oligomeric matrix protein (COMP) is a marker of joint destruction in rheumatoid arthritis (RA).
  • Identifying treatments that reduce joint damage progression is crucial for RA management.

Purpose of the Study:

  • To evaluate the effect of tocilizumab (TCZ) on serum COMP levels in RA patients.
  • To compare TCZ's effect on COMP levels in patients previously treated with anti-TNF therapy versus disease-modifying anti-rheumatic drugs (DMARDs).

Main Methods:

  • Fifty-one RA patients unresponsive to DMARDs and anti-TNF drugs received TCZ (8 mg/kg/month) for six months.
  • Serum COMP levels, DAS28 scores, ESR, CRP, IL-6, RF (IgM, IgG, IgA), and anti-CCP autoantibodies were measured at baseline and after six months.

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Main Results:

  • TCZ treatment led to significant reductions in ESR, CRP, IL-6, TNF-α, and DAS28 scores (P < 0.0001).
  • Serum COMP levels showed a non-significant decrease (P = 0.9856) after six months.
  • A decrease in COMP levels was observed in both anti-TNF and anti-DMARD failure groups without significant difference.

Conclusions:

  • TCZ effectively reduces inflammation and disease activity in long-standing RA patients.
  • TCZ demonstrates a trend towards decreasing serum COMP levels, particularly in patients with prior anti-TNF treatment failure.
  • These findings suggest TCZ may impact cartilage destruction in RA, warranting further investigation.