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Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
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Updated: Apr 18, 2026

Improved UPLC-UV Method for the Quantification of Vitamin C in Lettuce Varieties Lactuca sativa L. and Crop Wild Relatives Lactuca spp.
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Split-face vitamin C consumer preference study.

Leslie Baumann, Deysi K Duque, Michael J Schirripa

    Journal of Drugs in Dermatology : JDD
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    This summary is machine-generated.

    Two professional vitamin C serums and sunscreens were compared for anti-aging efficacy. Products A demonstrated superior results, with users preferring their scent, feel, and application over Products B.

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    Area of Science:

    • Dermatology and Cosmetic Science
    • Topical Formulations
    • Anti-aging Skincare Research

    Background:

    • Vitamin C is a key ingredient for anti-aging, offering antioxidant, tyrosinase inhibition, and collagen synthesis benefits.
    • Current vitamin C formulations vary in pH, packaging, and vehicle, potentially impacting absorption and efficacy.
    • Optimizing topical vitamin C delivery is crucial for effective aged skin treatment.

    Purpose of the Study:

    • To evaluate and compare the subjective efficacy, wearability, tolerance, and overall preference of two distinct professional vitamin C topical serums and sunscreen combinations.
    • To assess user experience with different anti-aging skincare formulations in Caucasian females.
    • To determine user preference between two leading vitamin C and SPF product pairings.

    Main Methods:

    • A virtual split-face study involving 39 Caucasian women.
    • Comparison of two product combinations: Products A (Jan Marini) and Products B (SkinCeuticals).
    • Subjects provided feedback via 5 online surveys over 14 days, assessing various product attributes.

    Main Results:

    • Over 86% of subjects preferred the scent and 83% preferred the feel/application of Vitamin C Serum A over Serum B.
    • 71% preferred the feel/application of Sunscreen A over Sunscreen B.
    • Products A showed significant improvements in skin texture and tone compared to Products B.

    Conclusions:

    • Products A demonstrated superior anti-aging benefits compared to Products B.
    • Subjects showed a significant preference for the sensory attributes and application of Products A.
    • Products A were associated with less irritation and higher user willingness to pay.