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Trace elements in children suffering from idiopathic nephrotic syndrome
Sebahat Tulpar1, Zubeyde Gunduz1, Ugur Sahin2
1Department of Pediatric Nephrology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
The Eurasian Journal of Medicine
|January 23, 2015
Summary
Idiopathic nephrotic syndrome patients show lower plasma zinc and selenium levels. Urinary boron and selenium increase during active phases, suggesting trace element imbalances in this condition.
Area of Science:
- Biochemistry
- Clinical Nutrition
- Pediatric Nephrology
Background:
- Trace elements are vital for metabolic functions.
- These elements bind to proteins in circulation.
- Understanding their role in nephrotic syndrome is crucial.
Purpose of the Study:
- To assess selenium, zinc, and boron status in idiopathic nephrotic syndrome.
- To compare trace element levels in active and remission phases.
- To investigate potential links between trace elements and disease activity.
Main Methods:
- Inductively coupled plasma mass spectrometry (ICP-MS) was used.
- Plasma and urinary levels of selenium, zinc, and boron were measured.
- Fourteen patients and fourteen age-matched healthy controls participated.
Main Results:
- Significantly lower plasma zinc and selenium in patients (active and remission).
- Significantly lower plasma boron in active phase patients.
- Higher urinary boron and selenium during active phase compared to remission.
Conclusions:
- Patients with idiopathic nephrotic syndrome exhibit altered trace element profiles.
- Zinc, selenium, and boron supplementation may benefit patients.
- Further research into trace element metabolism in nephrotic syndrome is warranted.
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