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Related Experiment Video

Updated: Apr 18, 2026

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

Identifying reactive peptides from phage-displayed libraries.

Glenn M Eldridge¹, Gregory A Weiss

¹Science and Math Division, West Valley College, Saratoga, CA, USA.

Methods in Molecular Biology (Clifton, N.J.)

|January 25, 2015

Summary

This summary is machine-generated.

Phage display technology allows for the selection of peptides that bind to specific targets. This study details methods to identify peptides that can selectively bind to or react with small molecules.

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Area of Science:

Biotechnology
Molecular Biology
Chemical Biology

Background:

Phage display is a powerful technique for generating and screening vast polypeptide libraries (over 10^10 members).
These libraries can identify binding partners for a wide range of targets.
Peptides that interact with small molecules are valuable for applications like targeted protein labeling.

Purpose of the Study:

To describe protocols for selecting and screening short peptides.
To identify peptides with selective binding or reactivity towards small molecules.

Main Methods:

Utilizing phage display for library synthesis and screening.
Developing selection strategies to isolate peptides with small molecule affinity.
Implementing screening assays to confirm peptide-small molecule interactions.

Main Results:

Identification of specific short peptides capable of binding to small molecules.
Demonstration of selective interactions between identified peptides and target small molecules.
Validation of the described selection and screening protocols.

Conclusions:

Phage display is effective for identifying peptides that interact with small molecules.
The developed protocols enable the discovery of peptides for targeted small molecule applications.
These findings advance peptide-based tools for chemical biology and protein labeling.