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Updated: Apr 18, 2026

Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
Published on: July 23, 2020
[Anesthetic aspects of brain dislocation syndrome]
Abstract:
The article presents a comparative analysis of the proposed methods of intensive care to eliminate/reduce the development of syndrome of displacement of the brain during neurosurgical operations with known and accepted algorithms and recommendations. The aim of this work was the detailed specification of the activities of the anesthesiologist with the introduction of some moments in the existing algorithms for minimizing the negative effects of the dislocation of the brain at the stage of decompression of the cranial cavity during neurosurgical operations. Analyzed intraoperative period at runtime techniques in 49 patients during operations regarding severe closed craniocerebral injury complicated by the formation of subdural and epidural hematomas. In a comparative aspect between groups there were no statistically significant differences in the results of blood pressure and heart rate dynamics (for hemodynamic stabilization), but a more rapid effect was achieved within the temporary components in patients surveyed group. The use of low volume correction by stream introduction of crystalloid and colloid solutions followed by introduction of saluretics with the parallel change of narcosis and simultaneous short-term "acute" hyperventilation with minimal doses of sympathomimetics infusion allows for a relatively short time to stabilize hemodynamics and reduce the development of syndrome of displacement of the brain.
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