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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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MALDI-TOF Mass Spectrometry01:19

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Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
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A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
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Can proteomics-based diagnostics aid clinical psychiatry?

Michaela D Filiou1

  • 1Max Planck Institute of Psychiatry, Munich, Germany.

Proteomics. Clinical Applications
|January 27, 2015
PubMed
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Proteomics shows promise for diagnosing psychiatric disorders but faces significant translational challenges. Realistic expectations and pragmatic approaches are crucial for developing effective proteomics-based blood tests.

Keywords:
Blood testsClinical proteomicsDiagnosticsImplementationPsychiatric disorders

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Area of Science:

  • Clinical proteomics
  • Psychiatric diagnostics
  • Translational science

Background:

  • Despite advancements in proteomics technology, clinical applications have lagged behind expectations.
  • Translational research in proteomics faces hurdles in bridging basic science and clinical practice.

Purpose of the Study:

  • To explore the potential of proteomics-based diagnostics in clinical psychiatry.
  • To outline challenges and provide directions for successful clinical implementation of proteomics.
  • To assess the feasibility of blood tests for psychiatric disorders using proteomics.

Main Methods:

  • This viewpoint discusses the challenges and potential of proteomics in clinical psychiatry.
  • It reviews current limitations in translational proteomics.
  • It examines specific challenges posed by psychiatric disorders for proteomic analysis.

Main Results:

  • Proteomics offers a powerful toolkit for clinical translation in psychiatry.
  • Significant challenges exist in implementing proteomics-based diagnostics clinically.
  • Psychiatric disorders present unique difficulties for proteomic biomarker discovery.

Conclusions:

  • Proteomics holds potential for psychiatric diagnostics, particularly through blood tests.
  • A pragmatic approach with realistic expectations is necessary for clinical translation.
  • Further research and strategic implementation are needed to realize proteomics' clinical utility.