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Updated: Apr 18, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
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Neuropsychiatric scurvy.

Thomas M Brown1

  • 1Audie L. Murphy Memorial Veterans Administration Center, San Antonio, TX.

Psychosomatics
|January 27, 2015
PubMed
Summary
This summary is machine-generated.

Scurvy, a condition known for bleeding and pain, may also affect the central nervous system. This review explores neuropsychiatric scurvy, its causes, diagnosis, and treatment.

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Area of Science:

  • Neurology
  • Nutritional Science
  • Medical History

Background:

  • Scurvy is traditionally recognized for peripheral manifestations like bleeding gums and skin hemorrhages.
  • Limited awareness exists regarding potential central nervous system involvement in scurvy.

Purpose of the Study:

  • To review the clinical and historical evidence for a distinct form of scurvy impacting the central nervous system.
  • To describe the pathophysiology, diagnosis, and management of neuropsychiatric scurvy.

Main Methods:

  • Comprehensive review of clinical case studies and historical medical literature.
  • Analysis of pathophysiologic mechanisms related to vitamin C deficiency and neurological function.
  • Examination of diagnostic criteria and therapeutic strategies for neuropsychiatric scurvy.

Main Results:

  • Evidence suggests a specific manifestation of scurvy, termed neuropsychiatric scurvy, affects the central nervous system.
  • Pathophysiological factors contributing to neurological symptoms in vitamin C deficiency are elucidated.
  • Diagnostic approaches and management protocols for this condition are outlined.

Conclusions:

  • Neuropsychiatric scurvy represents a significant, though often overlooked, complication of vitamin C deficiency.
  • Recognition and timely management are crucial for addressing the neurological sequelae of scurvy.