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[Sublingual enalapril in hypertensive crisis. A preliminary study]
Anales De Medicina Interna (Madrid, Spain : 1984)
|August 1, 1989
Summary
Sublingual enalapril, an angiotensin I-converting enzyme inhibitor (ACEI), effectively lowered blood pressure in hypertensive crisis patients. This ACEI demonstrated a sustained hypotensive effect without impacting heart rate, proving useful for elderly patients.
Area of Science:
- Cardiology
- Pharmacology
Context:
- Hypertension crisis presents a significant risk, particularly in elderly patients.
- Effective and safe management strategies are crucial for immediate blood pressure reduction.
Purpose:
- To evaluate the efficacy and safety of sublingual enalapril in managing hypertension crisis.
- To assess the onset, duration, and cardiovascular effects of sublingual enalapril administration.
Summary:
- Sublingual enalapril was administered to 16 hypertensive crisis patients (mean age 60.5 years).
- A significant reduction in systolic and diastolic blood pressure was observed within 20 minutes, sustained for 60 minutes.
- No significant changes in cardiac rate or adverse effects were noted.
Impact:
- Sublingual enalapril offers a gradual and sustained hypotensive effect suitable for non-urgent hypertension crisis in the elderly.
- This administration route facilitates the transition to oral antihypertensive therapy.