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[Enalapril in essential arterial hypertension]
Revista Medica De Chile
|June 1, 1989
Summary
Enalapril, a converting enzyme inhibitor, effectively lowers blood pressure in mild to moderate hypertension when used as a single daily therapy. It achieved normal blood pressure in 6 of 17 patients, demonstrating safety and efficacy.
Area of Science:
- Cardiology
- Pharmacology
Context:
- Hypertension management is a critical aspect of cardiovascular health.
- Converting enzyme inhibitors represent a key therapeutic class for blood pressure control.
Purpose:
- To prospectively evaluate the efficacy and safety of enalapril as a single daily agent for hypertension over 16 weeks.
- To determine the proportion of patients achieving normal blood pressure levels with enalapril monotherapy.
Summary:
- A 16-week prospective study assessed enalapril in 20 subjects with mild to moderate hypertension.
- Significant blood pressure reduction (p<0.01) was observed, with 6 of 17 patients reaching normal levels.
- Enalapril was generally well-tolerated, with minor side effects reported in 3 patients. It proved effective as a first-line monotherapy for mild/moderate cases.
Impact:
- Enalapril demonstrates potential as a safe and effective first-line monotherapy for mild to moderate hypertension.
- Adjunctive therapy with hydrochlorothiazide may be necessary for severe hypertension cases.
- The study supports enalapril's role in initiating hypertension treatment regimens.