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Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

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Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
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Updated: Apr 18, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
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Diastolic dysfunction characterizes cirrhotic cardiomyopathy.

Piyush O Somani1, Qais Contractor2, Ajay S Chaurasia3

  • 1Lecturer, Department of Gastroenterology, BYL Nair Ch Hospital & Topiwala National Medical College, Dr A L Nair Road, Mumbai Central, Mumbai, Maharashtra 400008, India.

Indian Heart Journal
|January 31, 2015
PubMed
Summary
This summary is machine-generated.

Cirrhotic cardiomyopathy, characterized by mild diastolic dysfunction, is common in liver cirrhosis but doesn't correlate with liver disease severity or hepatorenal syndrome (HRS). Cardiac function in cirrhosis patients showed no significant differences based on etiology or disease stage.

Keywords:
CardiomyopathyCirrhosisCirrhotic cardiomyopathyDiastolic dysfunction

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Area of Science:

  • Cardiology
  • Hepatology
  • Internal Medicine

Background:

  • Cirrhosis of the liver is frequently associated with cardiac abnormalities, collectively termed cirrhotic cardiomyopathy.
  • The relationship between cirrhotic cardiomyopathy and the development of hepatorenal syndrome (HRS) remains incompletely understood.

Purpose of the Study:

  • To investigate the prevalence of cirrhotic cardiomyopathy in patients with liver cirrhosis.
  • To assess the correlation between cardiac dysfunction and the incidence of hepatorenal syndrome (HRS).

Main Methods:

  • Echocardiography was used to evaluate cardiac parameters in 60 cirrhotic patients (30 alcoholic, 30 non-alcoholic) and 30 healthy controls.
  • Patients were monitored for 12 months to track the development of HRS.

Main Results:

  • Mild diastolic dysfunction (Grade I or II) was observed in 30% of cirrhotic patients.
  • No significant differences in echocardiographic parameters were found between alcoholic and non-alcoholic cirrhotic patients, or across different Child-Pugh classes.
  • Only deceleration time showed statistical significance; HRS developed in two patients, with no significant correlation to diastolic dysfunction.

Conclusions:

  • Diastolic dysfunction is common in cirrhosis but typically mild and not linked to liver dysfunction severity.
  • Cardiac parameters do not differ significantly between alcoholic and non-alcoholic cirrhosis.
  • Diastolic dysfunction in cirrhosis is not correlated with HRS, circulatory dysfunction, or ascites, and does not impact one-year survival.