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Using deconvolution to understand the mechanism for variable plasma concentration-time profiles after intramuscular

Adnan H Mahmood1, Xin Liu2, Jeffrey E Grice2

  • 1Therapeutics Research Centre, UQ School of Medicine, Translational Research Institute, 37 Kent St., Woolloongabba, Qld 4102, Australia; The Technical Institute of Baqubah, Foundation of Technical Education, Iraq.

International Journal of Pharmaceutics
|February 1, 2015
PubMed
Summary

Marbofloxacin (MBX) and trovafloxacin (TVX) pharmacokinetics in sheep revealed MBX follows first-order absorption, while TVX exhibits zero-order absorption due to injection site precipitation.

Keywords:
AntibioticsDeconvolutionIntramuscular injection

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