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Analgesic principle from Curcuma amada.
Chowdhury Faiz Hossain1, Mohammad Al-Amin1, Kazi Md Mahabubur Rahman1
1Department of Pharmacy, East West University, A/2, Jahurul Islam Avenue, Aftabnagar, Dhaka 1212, Bangladesh.
Journal of Ethnopharmacology
|February 1, 2015
Summary
The study identified zederone as the active analgesic compound in Curcuma amada rhizome. This finding scientifically validates the traditional use of this plant for pain relief in various medicinal systems.
Area of Science:
- Pharmacology
- Natural Products Chemistry
- Ethnomedicine
Background:
- Curcuma amada rhizome is traditionally used for rheumatic disorders, inflammation, and fever in Bangladesh, Ayurvedic, and Unani medicine.
- Investigating the scientific basis of these traditional uses is crucial for pharmacological validation.
Purpose of the Study:
- To isolate and identify the analgesic principle from the methanol (MeOH) extract of Curcuma amada rhizome.
- To elucidate the chemical structure of the purified compound using spectroscopic methods.
Main Methods:
- Extraction of Curcuma amada rhizome with methanol (MeOH).
- In vivo analgesic activity evaluation using acetic acid-induced writhing and formalin-induced licking tests in mice.
- Chromatographic separation (VLC, column chromatography) and crystallization for purification.
- Structure elucidation via spectroscopic techniques.
Main Results:
- The MeOH extract showed significant dose-dependent inhibition of writhing and licking responses.
- Vacuum Liquid Chromatography (VLC) fraction 1 exhibited potent analgesic activity.
- Further purification led to the isolation of zederone (1) from fraction SF. 2.
- Zederone demonstrated statistically significant analgesic effects in both tested models at low doses (20-40 mg/kg).
Conclusions:
- Zederone is identified as the primary analgesic compound in Curcuma amada rhizome.
- This isolation and characterization scientifically support the ethnomedicinal applications of Curcuma amada for pain management.
- The findings contribute to the pharmacological validation of traditional medicine practices.
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