Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antibiotics and inflammatory bowel diseases.

G Gitnick1

  • 1Department of Medicine, UCLA School of Medicine.

Gastroenterology Clinics of North America
|March 1, 1989
PubMed
Summary

Limited evidence supports most antibiotic use for inflammatory bowel diseases. Metronidazole shows promise for specific Crohn's disease cases, but side effects restrict long-term application.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alginate microbead release assay of angiogenesis.

Methods in molecular medicine·2011
Same author

Extensive in vivo angiogenesis following controlled release of human vascular endothelial cell growth factor: implications for tissue engineering and wound healing.

Artificial organs·2001
Same author

Hepatitis C screening strategies in hemodialysis patients.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2001
Same author

Automated RIBA HCV strip immunoblot assay: a novel tool for the diagnosis of hepatitis C virus infection in hemodialysis patients.

American journal of nephrology·2001
Same author

Long-term mortality and morbidity of transfusion-associated non-A, non-B, and type C hepatitis: A National Heart, Lung, and Blood Institute collaborative study.

Hepatology (Baltimore, Md.)·2001
Same author

Serum alanine aminotransferase in hepatitis c screening of patients on hemodialysis.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2001

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Antibiotic use in inflammatory bowel diseases (IBD) lacks robust evidence.
  • Current data is insufficient to broadly recommend antibiotics for Crohn's disease or ulcerative colitis.

Purpose of the Study:

  • To evaluate the existing medical literature on antibiotic efficacy in IBD treatment.
  • To identify specific antibiotic uses supported by current research.

Main Methods:

  • Systematic review of medical literature concerning antibiotics and IBD.
  • Analysis of data supporting antibiotic use in Crohn's disease and ulcerative colitis.

Main Results:

  • Most antibiotics lack sufficient evidence for widespread IBD treatment.
  • Metronidazole is supported for selected Crohn's disease patients, particularly with perianal disease or fistulae.
  • Significant side effects of metronidazole may limit its long-term use.

Conclusions:

  • Evidence for most antibiotic use in IBD is inadequate.
  • Metronidazole offers a potential treatment option for specific Crohn's disease manifestations, but its use requires careful consideration of side effects.

Related Experiment Videos