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Updated: Apr 18, 2026

Using Multilayered Hydrogel Bioink in Three-Dimensional Bioprinting for Homogeneous Cell Distribution
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A multimaterial bioink method for 3D printing tunable, cell-compatible hydrogels.

Alexandra L Rutz1, Kelly E Hyland, Adam E Jakus

  • 1Simpson Querrey Institute for BioNanotechnology, Chicago, IL, 60611, USA; Department of Biomedical Engineering, Evanston, IL, 60208, USA.

Advanced Materials (Deerfield Beach, Fla.)
|February 3, 2015
PubMed
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This study introduces a new multimaterial bio-ink using polyethylene glycol crosslinking to create soft hydrogels. This method enhances 3D bioprinting for customizable tissue and organ constructs.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Bioprinting Technologies

Background:

  • 3D bioprinting requires diverse biomaterials for creating complex tissue constructs.
  • Current bio-ink limitations hinder the development of highly mimetic and customizable organ models.
  • Polyethylene glycol (PEG) is a versatile polymer for hydrogel development.

Purpose of the Study:

  • To present a novel multimaterial bio-ink synthesis strategy.
  • To expand the range of available biomaterials for 3D bioprinting.
  • To enable the fabrication of more customizable and biomimetic tissue and organ constructs.

Main Methods:

  • Development of a multimaterial bio-ink formulation utilizing polyethylene glycol (PEG) crosslinking.
  • Fabrication of lightly crosslinked, soft hydrogels from precursor solutions of various materials.
Keywords:
3D printingbiofabricationbioprintinghydrogelstissue engineering

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  • 3D printing of the developed hydrogel constructs.
  • Rheological and biological characterization of the synthesized bio-inks and printed constructs.

    • Main Results:

    • Successful synthesis of a multimaterial bio-ink system.
    • Production of soft, lightly crosslinked hydrogels with tunable properties.
    • Demonstration of 3D printability for creating intricate structures.
    • Initial characterization indicating suitability for tissue engineering applications.

    Conclusions:

    • The presented bio-ink method offers a promising strategy for advancing 3D bioprinting.
    • This approach expands the biomaterial options for creating sophisticated tissue and organ models.
    • Further research can explore the full potential of this technique for regenerative medicine.