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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Extraction: Advanced Methods00:56

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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
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Complexation Equilibria: The Chelate Effect01:19

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In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
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Targeted Chemotherapy with Metal Complexes.

Alyson G Weidmann1, Alexis C Komor1, Jacqueline K Barton1

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125.

Comments on Modern Chemistry. Part A, Comments on Inorganic Chemistry : a Journal of Critical Discussion of the Current Literature
|February 3, 2015
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Summary
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Targeted anticancer agents, like rhodium metalloinsertors, show promise for reducing chemotherapy side effects by selectively targeting cancer biomolecules, particularly DNA mismatches.

Keywords:
DNA mismatch repairbioinorganicmedicinal chemistry

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Area of Science:

  • Oncology
  • Medicinal Chemistry
  • Molecular Biology

Background:

  • Classical chemotherapeutics, such as cisplatin, are effective but cause significant side effects due to non-specific cell killing.
  • Targeted anticancer agents aim to improve selectivity and reduce side effects by focusing on specific cancer biomarkers.

Purpose of the Study:

  • To discuss transition metal complexes designed as targeted anticancer agents.
  • To highlight the potential of these novel strategies in cancer therapy.

Main Methods:

  • Review of transition metal complexes tailored for cancer-related biomolecules.
  • Focus on rhodium metalloinsertors that bind to DNA base mismatches.

Main Results:

  • Transition metal complexes offer a promising avenue for targeted cancer therapy.
  • Rhodium metalloinsertors demonstrate specific binding to DNA base mismatches, indicating high selectivity.

Conclusions:

  • Targeted therapies using transition metal complexes, particularly rhodium metalloinsertors, represent a significant advancement in chemotherapy.
  • This strategy holds potential for developing more effective anticancer drugs with fewer side effects.