[Genetics of atopic eczema. An update]

Eczema is a typical multifactorial disease which is based on an individual hereditary predisposition that becomes manifested by environmental and lifestyle factors. The heritability of eczema is estimated to be 70-80 %. The possibilities for deciphering inherited risk factors have significantly increased during recent years. As a result various genetic risk factors have been successfully identified and first insights into epigenetic changes have been obtained. With the growing knowledge about the constitutionally determined variability new disease models have been developed, which imply temporal and developmental interactions between genetic and environmental factors. Strategies for individualized prediction, prevention and therapy are conceivable.