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Related Experiment Videos

[Adhesion in meningococcus].

T K Mironova, N V Klitsunova, V V Gosteva

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |January 1, 1989
    PubMed
    Summary
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    Meningococcal strains from carriers show higher adhesive activity and pili compared to those from patients. Hemagglutination tests can effectively determine meningococcal adhesive capacity linked to pili.

    Area of Science:

    • Microbiology
    • Bacteriology
    • Infectious Diseases

    Background:

    • Neisseria meningitidis is a significant human pathogen.
    • Adhesive properties are crucial for bacterial colonization and infection.
    • Pili are known virulence factors involved in bacterial adhesion.

    Purpose of the Study:

    • To investigate the adhesive activity of various meningococcal strains.
    • To correlate adhesive properties with the presence of pili.
    • To evaluate the hemagglutination test as a measure of meningococcal adhesion.

    Main Methods:

    • Studied adhesive activity in 113 meningococcal strains and 10 nonpathogenic Neisseria strains.
    • Utilized hemagglutination assays to assess adhesive properties.
    • Employed electron microscopy to quantify pili on bacterial cells.

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    Main Results:

    • 80-82% of studied strains exhibited adhesive properties.
    • Meningococcal strains from nasopharyngeal carriers showed higher hemagglutinating activity.
    • A direct correlation was observed between pili presence and hemagglutination activity.

    Conclusions:

    • Adhesive properties are prevalent in meningococcal strains.
    • Hemagglutination activity is a reliable indicator of pili-associated adhesion in meningococci.
    • This finding facilitates the assessment of meningococcal adhesive capacity.