Related Experiment Video
Updated: Apr 17, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
Published on: July 8, 2025
Hippocampal seizure-onset laterality can change over long timescales: A same-patient observation over 500 days
Otis Smart1, John D Rolston2, Charles M Epstein3
1Department of Neurosurgery, Emory University School of Medicine, Woodruff Memorial Research Building, 101 Woodruff Circle, Room 6329, Atlanta, GA 30322, USA.
Abstract:
This study describes seizure laterality and localization changes over 500 consecutive days in a patient with bilateral temporal lobe epilepsy (BTLE) and implanted NeuroPace RNS™ System. During a continuous two-year time period, the RNS™ device stored 54 hippocampal electrocorticography (ECoG) seizures, which we analyzed to determine their distribution and time variance across hippocampi. We report nonrandom long-term seizure laterality and localization variations, especially in the first 200 days postimplant, despite equivalent total seizure counts in both hippocampi. This case suggests that hippocampal seizures dynamically progress over extensive timescales.
More Related Videos
14:27Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
07:03Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
Published on: July 31, 2019
Related Concept Videos
Role of Hippocampus in Memory
Lateralization
Seizures l: Introduction
Epilepsy ll: Types
Seizures ll: Types
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types: