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[Migraine and epilepsy].
1Department of Medical Technology and Sciences, School of Health Sciences at Fukuoka, International University of Health and Welfare.
Rinsho Shinkeigaku = Clinical Neurology
|February 13, 2015
Summary
Migraine and epilepsy share clinical features and pathophysiological mechanisms, with a complex temporal association. Research explores their bidirectional relationship and potential shared genetic basis.
Area of Science:
- Neurology
- Neuroscience
Background:
- Migraine and epilepsy are common episodic neurological disorders with known comorbidity.
- The temporal relationship between migraine and epilepsy is complex and debated, with various recognized associations between headache and epileptic seizures.
Observation:
- The International Classification of Headache Disorders, 3rd edition (ICHD-3) defines specific entities like migraine aura-triggered seizures (migralepsy) and post-ictal headaches.
- Previous reports of migralepsy often described occipital seizures mimicking migraine with aura, though the term is now debated.
- Migraine and epilepsy share underlying pathophysiological mechanisms, including neurotransmitter and ion channel dysfunctions.
Findings:
- A complex and bidirectional association exists between migraine and epilepsy.
- There is a hypothesis suggesting a shared genetic susceptibility to both migraine and epilepsy.
- Familial hemiplegic migraine provides strong support for a shared genetic basis.
Implications:
- Understanding the shared mechanisms and genetic links can lead to better diagnostic and therapeutic strategies for both conditions.
- Further research into the bidirectional relationship may clarify the causality and influence between migraine and epilepsy.
- Clarifying the controversial term 'migralepsy' and its underlying mechanisms is crucial for accurate diagnosis and treatment.
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