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Novel parameters in blood cell counters.

Thomas Pierre Lecompte1, Michael Pierre Bernimoulin1

  • 1Haematology Division, Faculty of Medicine, Hôpitaux Universitaires de Genève, Geneva University, Rue Gabrielle-Perret-Gentil 4, Geneva 14 CH-1211, Switzerland.

Clinics in Laboratory Medicine
|February 14, 2015
PubMed
Summary
This summary is machine-generated.

Modern automated cell counters provide new parameters like CHr (reticulocyte hemoglobin equivalent) for clinical use. However, comparing novel parameters, especially for inherited thrombocytopenia, across different platforms remains challenging.

Keywords:
AnemiaComplete blood cell countHematology analyzersNew parametersSchistocytesThrombocytopenia

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Area of Science:

  • Hematology
  • Clinical Pathology
  • Laboratory Medicine

Background:

  • Automated cell counters are increasingly offering novel parameters beyond basic blood counts.
  • Some parameters, such as reticulocyte hemoglobin equivalent (CHr) and immature platelet fraction, are gaining clinical acceptance.
  • The characterization of platelet volume in inherited thrombocytopenia presents a clinical challenge.

Purpose of the Study:

  • To review the utility and limitations of novel parameters from automated cell counters.
  • To discuss the application of these parameters in specific clinical scenarios like inherited thrombocytopenia.
  • To highlight the challenges in comparing results across different instrument platforms.

Main Methods:

  • Review of current literature and instrument specifications for automated cell counters.
  • Analysis of the clinical relevance of novel parameters, including CHr and immature platelet fraction.
  • Discussion of inter-platform variability for similar parameters.

Main Results:

  • Several novel parameters are available, with some, like CHr, integrated into clinical guidelines (e.g., for dialysis patients).
  • Other parameters are still in research phases, lacking established reference ranges.
  • Significant differences exist in parameter definitions and measurement methodologies between manufacturers, hindering cross-platform comparisons.

Conclusions:

  • Novel parameters in automated cell counters offer potential clinical insights, but standardization is lacking.
  • Inter-instrument comparability is a major hurdle for widespread adoption and reliable clinical application, particularly for rare conditions like inherited thrombocytopenia.
  • Further research and standardization efforts are needed to fully leverage the capabilities of modern cell counters.