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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

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New antifungal and antiviral dosing

Kelly C Wade1, Heather M Monk2

  • 1Division of Neonatology, Department of Pediatrics, Perelman School of Medicine, Children's Hospital of Philadelphia Newborn Care at Pennsylvania Hospital, 800 Spruce Street, Philadelphia, PA 19107, USA.

Clinics in Perinatology
|February 14, 2015
PubMed

Insights

Neonatal fungal and viral infections pose serious risks. Understanding antimicrobial pharmacokinetics (PK) and pharmacodynamics (PD) improves medication dosing, enhancing treatment for newborns.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Pharmacology

Background:

  • Neonatal fungal and viral infections are significant causes of mortality and long-term neurologic disability.
  • Effective treatment is crucial for improving outcomes in vulnerable newborns.

Purpose of the Study:

  • To review the fundamental pharmacokinetic (PK) and pharmacodynamic (PD) properties of common neonatal antifungal and antiviral drugs.
  • To provide updated dosing guidance for these critical medications in neonates.

Main Methods:

  • Literature review of PK/PD studies and clinical trials concerning neonatal antifungal and antiviral therapies.
  • Synthesis of current evidence on drug disposition and efficacy in the neonatal population.

Main Results:

  • Established PK/PD principles guide optimized antimicrobial dosing in neonates.
  • Specific recommendations for common antifungal and antiviral agents are discussed.

Conclusions:

  • Optimized dosing strategies based on PK/PD are essential for managing neonatal infections.
  • Further research into neonatal antimicrobial pharmacology can improve patient care and reduce morbidity and mortality.

Keywords:
AcyclovirAmphotericinEchinocandinFluconazoleGanciclovirNeonate

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