Solid state adsorption of antibiotics onto sorbitol

Area of Science:

• Pharmaceutical Sciences
• Materials Science

Background:

• Sorbitol is utilized as an excipient in pharmaceutical formulations.
• Understanding the interaction between sorbitol and antibiotics is crucial for drug delivery.

Purpose of the Study:

• To evaluate the adsorption capacity and binding strength of instant and crystalline sorbitol for antibiotics.
• To categorize antibiotics based on their adsorption behavior onto sorbitol.

Main Methods:

• Air sieving technique was employed to assess antibiotic adsorption onto sorbitol.
• Six different antibiotics were tested for their binding characteristics.

Main Results:

• Instant sorbitol exhibited higher adsorption capacity and binding strength than crystalline sorbitol.
• Antibiotics were grouped into two categories based on adsorption levels, with pivampicillin, cephalexin monohydrate, and erythromycin ethylsuccinate showing higher adsorption.
• A negative linear relationship was observed between adsorbed and added antibiotic amounts.
• Adsorption data suggested an apparent Langmuir isotherm, indicating specific binding sites.

Conclusions:

• Instant sorbitol is a more effective carrier for antibiotic adsorption than crystalline sorbitol.
• Antibiotic adsorption onto sorbitol is dependent on the specific antibiotic and available binding sites.