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3D Ultrasound Imaging: Fast and Cost-effective Morphometry of Musculoskeletal Tissue
Published on: November 27, 2017
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Muscling in on the third dimension.
Mohsen Afshar Bakooshli1, Penney M Gilbert2
1Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada.
Elife
|February 17, 2015
Summary
Creating a functional 3D human skeletal muscle model can speed up the development of new treatments for muscle disorders. This innovation offers personalized therapeutic approaches for patients.
Area of Science:
- Biomedical Engineering
- Tissue Engineering
- Regenerative Medicine
Background:
- Skeletal muscle disorders represent a significant health burden.
- Current treatment options are limited and often lack personalization.
- A need exists for advanced models to study muscle physiology and disease.
Purpose of the Study:
- To develop a functional three-dimensional (3D) model of human skeletal muscle tissue.
- To establish a platform for studying skeletal muscle disorders.
- To facilitate the discovery of personalized therapeutic strategies.
Main Methods:
- Utilized advanced biomaterials and cell culture techniques.
- Engineered a 3D scaffold to mimic the native muscle extracellular matrix.
- Incorporated human skeletal muscle cells to form functional tissue.
Main Results:
- Successfully generated a viable and functional 3D human skeletal muscle tissue model.
- Demonstrated tissue contractility and appropriate cellular organization.
- The model exhibited key characteristics of native skeletal muscle.
Conclusions:
- The developed 3D skeletal muscle model holds significant potential for research.
- It can accelerate the testing and development of novel therapeutic interventions.
- This platform is a crucial step towards personalized medicine for muscle disorders.
Keywords:
contractile forcedrug testinghumanhuman biologyhuman skeletal musclemedicinemuscle physiologytissue engineeringMore Related Videos
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