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Late-onset toxic anterior segment syndrome
Goichiro Miyake1, Ichiro Ota1, Kensaku Miyake1
1From the Department of Ophthalmology (G. Miyake, Zako, Iwaki), Aichi Medical University, Aichi, the Shohzankai Medical Foundation (G. Miyake, Ota, K. Miyake), Miyake Eye Hospital, Nagoya, and Hoya Corporation Medical Division (Shibuya), Tokyo, Japan.
Journal of Cataract and Refractive Surgery
|February 18, 2015
Summary
Late-onset toxic anterior segment syndrome occurred in patients after acrylic intraocular lens implantation. Aluminum toxicity from the IOL production process was identified as the likely cause of this inflammation.
Area of Science:
- Ophthalmology
- Materials Science
Background:
- A series of six patients developed intraocular inflammation post-implantation of a specific acrylic foldable intraocular lens (IOL).
- This inflammation occurred between 42 and 137 days after surgery and was unresponsive to antibiotic therapy.
Observation:
- Simultaneously, an epidemic of sterile anterior segment inflammation with similar characteristics was observed, linked to the same IOL model.
- Clinical presentation suggested late-onset toxic anterior segment syndrome.
Findings:
- Analysis indicated that aluminum toxicity, stemming from the IOL manufacturing process, was the probable cause of the inflammation.
- The contamination risk persists despite modern manufacturing techniques.
Implications:
- This study highlights a potential risk of intraocular inflammation due to manufacturing-related IOL toxicity.
- It underscores the importance of rigorous quality control in IOL production to prevent adverse patient outcomes.
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