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Updated: Apr 17, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Subclinical hyperthyroidism impacts left ventricular deformation: 2D and 3D echocardiographic study.
Marijana Tadic1, Sanja Ilic, Cesare Cuspidi
1Department of Cardiology, University Clinical Hospital Center "Dr. Dragisa Misovic - Dedinje" , Belgrade , Serbia.
Subclinical hyperthyroidism impairs left ventricular (LV) function and mechanics, as shown by reduced LV deformation using three-dimensional echocardiography (3DE) and speckle tracking. Thyroid hormone levels correlate with these cardiac changes.
Area of Science:
- Cardiology
- Endocrinology
- Medical Imaging
Background:
- Subclinical hyperthyroidism (SCH) may affect cardiac function.
- Investigating left ventricular (LV) mechanics in SCH is crucial.
Purpose of the Study:
- To assess LV function and mechanics in SCH patients using 3D echocardiography (3DE) and speckle tracking.
- To correlate cardiac findings with thyroid hormone levels.
Main Methods:
- Included 35 untreated women with SCH and 35 age-matched healthy controls.
- Performed complete 2D and 3D echocardiography (2DE and 3DE) examinations.
- Measured serum thyroid hormone levels (TSH, FT4).
Main Results:
- SCH patients showed decreased 2DE LV longitudinal and circumferential strain.
- Reduced systolic and early diastolic strain rates, with increased late diastolic strain rates observed in SCH.
- 3DE revealed elevated LV end-diastolic volume and cardiac output, with significantly lower LV deformation and area strain in SCH.
Conclusions:
- LV deformation assessed by 3DE and speckle tracking is significantly impaired in subclinical hyperthyroidism.
- Thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels correlate with LV structure and mechanics.
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