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T-cell/histiocyte-rich large B-cell lymphoma in pediatric patients: an under-recognized entity?
Gabriela Gheorghe1, Hemalatha G Rangarajan2, Bruce Camitta3
1Department of Pathology and Laboratory Medicine, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI ggheorghe@mcw.edu.
Abstract:
T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a distinct subtype of diffuse large B-cell lymphoma (DLBCL) under-recognized in the pediatric population. A meticulous workup is necessary to avoid a misdiagnosis of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) or classical Hodgkin lymphoma (HL). A strong degree of suspicion and an emphasis on immunohistochemical staining are required to reach the diagnosis. Few children with advanced stage disease have been described to date. We report two pediatric patients with high stage THRLBCL and highlight their clinical and pathological features.
