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Updated: Apr 17, 2026

Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb
Published on: December 2, 2017
[A prolonged capillary refill is predictor of low central venous oxygen saturation]
Insights
A prolonged capillary refill time (>2 seconds) effectively predicts low central venous oxygen saturation (<70%) in pediatric intensive care patients. This finding supports current guidelines and may aid emergency care where central venous access is limited.
Area of Science:
- Pediatric critical care medicine
- Hemodynamic monitoring
- Shock management
Context:
- Pediatric life support guidelines recommend capillary refill time (CRT) >2 seconds as a shock indicator.
- Central venous catheter (CVC) insertion for central venous oxygen saturation (ScvO2) monitoring can be a barrier in emergency settings.
- Early goal-directed therapy in pediatric emergencies often faces challenges with invasive monitoring.
Purpose:
- To determine if CRT >2 seconds can predict ScvO2 <70% in pediatric intensive care unit (ICU) patients.
- To validate CRT as a non-invasive predictor of adequate tissue perfusion.
- To assess the utility of CRT in resource-limited emergency environments.
Summary:
- A prospective study involving 48 pediatric ICU patients measured ScvO2 and CRT simultaneously.
- Results showed an inverse correlation between CRT and ScvO2 (r=-0.58).
- ROC curve analysis demonstrated excellent predictive ability for CRT >2 seconds to identify ScvO2 <70% (AUC 0.94).
Impact:
- Prolonged CRT (>2 seconds) is a validated predictor of low ScvO2 in pediatric ICU patients.
- Supports current pediatric life support recommendations for shock assessment.
- Offers a valuable, non-invasive assessment tool for emergency departments where CVC and ScvO2 monitoring are unavailable.
Introduction:
Educational programs in pediatric life support endorse a capillary refill time>2 s as an indicator of shock. In the emergency room, a barrier to the implementation of an early goal directed therapy, aiming at central venous oxygen saturation (ScvO2)≥70% is the insertion of central venous catheter (CVC).
Objective:
To establish the predictive value of capillary refill time>2 s to detect ScvO2<70% in children admitted to Intensive Care Units.
Patients And Method:
Prospective study. We included 48 children admitted in the first 24 hours in ICU with superior vena cava CVC. Simultaneously, we measured ScvO2 and capillary refill time in the heel of upper extremity or toe.
Results:
There were 75 paired measurements ScvO2 (75,9±8,4%) and capillary refill capillary (1,9±1,0 s). We found an inverse correlation between capillary refill time and ScvO2 (r-0,58). The ROC curve analysis revealed an excellent ability for the capillary fill time>2 s to predict ScvO2<70% (AUC 0,94) (95% CI 0,87-0,98).
Conclusions:
A prolonged capillary refill time>2 s, is a predictor of ScvO2<70% in children admitted to ICU, which supports the current recommendations. This finding may be relevant in emergency units where the use of CVC is limited and ScvO2 is not available.
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