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Updated: Apr 17, 2026

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
Published on: September 6, 2017
[Renal function in pediatric patients with allogeneic hematopoietic progenitor cell transplantation]
Insights
Pediatric patients undergoing hematopoietic stem cell transplantation frequently experience kidney injury. This study found nearly half of pediatric transplant recipients showed signs of renal compromise, highlighting the need for ongoing kidney function assessment.
Area of Science:
- Pediatric Nephrology
- Hematology
- Transplantation Medicine
Unlabelled:
Patients with hematopoietic stem cell transplantation can develop some degree of renal failure. The aim of this descriptive study is to evaluate markers of kidney injury in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation between 1991 and 2011.
Patients And Method:
A descriptive study of pediatric patients with allogeneic transplant of hematopoietic precursors between 1991 and 2011. The patients were between 1 month and 18 years of age at the time of the study and had at least 6 months of follow up. Clinical and nutritional history, continuous blood pressure monitoring (ABPM), urine tests, proteinuria, creatinine and renal and bladder ultrasonography imaging were evaluated.
Results:
During this period 65 patients were transplanted, of which 13 patients were included. 46% (n = 6) showed diverse degrees of renal compromise defined by altered renal parenchymal echogenicity, clinic or masked hypertension and/or microalbuminuria.
Conclusion:
In this clinical group, almost half of the patients patients had some degree of renal injury in their evolution. We consider essential to assess the renal function in the follow-up of these patients.
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