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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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Stability Evaluation of Ivermectin-Loaded Biodegradable Microspheres

Rossella Dorati1, Ida Genta1, Barbara Colzani1

  • 1Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy.

AAPS Pharmscitech
|February 22, 2015
PubMed

A stability study was performed on ivermectin (IVM)-loaded biodegradable microparticles intended for injection in dogs. The rational was to evaluate the performances upon irradiation of a drug, such as IVM, with a few criticalities with respect to its stability, and toxicity. The goal was to provide valuable information for pharmaceutical scientists and manufacturers working in the veterinary area. The microspheres based on poly(D,L-lactide) and poly-(ε-caprolactone) and loaded with IVM and with the addition of alpha-tocopherol (TCP) as antioxidant were prepared by the emulsion solvent evaporation method and sterilized by gamma irradiation. Microsphere characterization in term of size, shape, polymer, and IVM stability upon irradiation was performed. The results show that the type of polymer significantly affects microsphere characteristics and performances. Moreover, suitably stable formulations can be achieved only by TCP addition.

Keywords:
alpha-tocopherolgamma irradiationivermectinmicrospherespoly(D,L-lactide)poly-(ε-caprolactone)

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