Related Experiment Video
Updated: Apr 17, 2026
07:16
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
Published on: September 13, 2018
20.8K
Disease implications of the Hippo/YAP pathway
Steven W Plouffe1, Audrey W Hong1, Kun-Liang Guan1
1Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
Trends in Molecular Medicine
|February 24, 2015
Summary
The Hippo signaling pathway regulates organ size and tissue balance. Its dysregulation contributes to diseases like cancer by affecting cell growth, proliferation, and apoptosis.
Area of Science:
- Molecular Biology
- Cell Biology
- Developmental Biology
Background:
- The Hippo signaling pathway is crucial for organ size control and tissue homeostasis.
- Its core components are evolutionarily conserved from Drosophila melanogaster to mammals.
- This pathway integrates signals from GPCRs, cytoskeleton, cell-cell contact, and polarity.
Purpose of the Study:
- To summarize the role of the Hippo signaling pathway in development and disease.
- To highlight the regulatory mechanisms and consequences of Hippo pathway dysregulation.
Main Methods:
- Review of existing literature on the Hippo signaling pathway.
- Analysis of conserved components and regulatory inputs.
- Examination of the link between Hippo pathway activity and disease phenotypes.
Main Results:
- The Hippo pathway acts as a tumor suppressor, inhibiting cell growth when active.
- Genetic inactivation or downstream effector amplification leads to uncontrolled cell proliferation.
- Dysregulation is associated with decreased apoptosis and differentiation, promoting tumorigenesis.
Conclusions:
- The Hippo pathway is a critical regulator of cell proliferation, apoptosis, and differentiation.
- Aberrant Hippo signaling is implicated in various diseases, including cancer.
- Understanding Hippo pathway modulation is key for therapeutic strategies.
Related Concept Videos
02:33Hedgehog Signaling Pathway
10.4K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.4K
02:33Hedgehog Signaling Pathway
1.9K
1.9K
03:14Notch Signaling Pathway
6.9K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.9K
01:19Interactions Between Signaling Pathways
8.0K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
8.0K
01:29Pharmacogenomics: Identification of New Drug Targets
95
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
95
01:22PI3K/mTOR/AKT Signaling Pathway
6.5K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
6.5K