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Effects of selective and non-selective beta 1-blockade on renin secretion in the isolated rat kidney
J M Haro1, F Vargas, M A Castillo
1Departamento de Bioquímica y Biologia Molecular, Facultad de Medicina, Granada, Spain.
Revista Espanola De Fisiologia
|June 1, 1989
Abstract:
The participation of beta 1-adrenoceptor on renin secretion was studied in perfused rat kidney. Administration of propranolol, inhibited the renin release mediated by isoproterenol. Likewise, metoprolol and practolol, showed a similar potency to propranolol in inhibiting isoproterenol-induced renin secretion. These results suggest that the for isoproterenol-induced renin release in rats is a beta 1-type adrenoceptor.