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Updated: Apr 17, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Crystal structure of 2-(1,3-dioxoindan-2-yl)iso-quinoline-1,3,4-trione
Raza Murad Ghalib1, C S Chidan Kumar2, Rokiah Hashim3
1Department of Chemistry, Faculty of Sciences & Arts Khulais, King Abdulaziz University, Jeddah, KSA.
Abstract:
In the title iso-quinoline-1,3,4-trione derivative, C18H9NO5, the five-membered ring of the indane fragment adopts an envelope conformation with the nitro-gen-substituted C atom being the flap. The planes of the indane benzene ring and the iso-quinoline-1,3,4-trione ring make a dihedral angle of 82.06 (6)°. In the crystal, mol-ecules are linked into chains extending along the bc plane via C-H⋯O hydrogen-bonding inter-actions, enclosing R 2 (2)(8) and R 2 (2)(10) loops. The chains are further connected by π-π stacking inter-ations, with centroid-to-centroid distances of 3.9050 (7) Å, forming layers parallel to the b axis.
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