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Updated: Sep 9, 2026

Crystallization of Membrane Proteins in Lipidic Mesophases
Published on: March 28, 2011
Crystal structure of racemic chloramphenicol
Odil Choriev1, Jamshid Ashurov1, Batirbay Torambetov2
1Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan, Mirzo Ulugbek Str. 83, Tashkent 100125, Uzbekistan.
Abstract:
The racemic title compound {systematic name: 2,2-di-chloro-N-[(1R,2R)-1,3-dihy-droxy-1-(4-nitro-phen-yl)propan-2-yl]acetamide}, C11H12Cl2N2O5, crystallizes in the space group P1. In the crystal, O-H⋯O, N-H⋯O and C-H⋯O hydrogen bonds link the mol-ecules into a three-dimensional architecture, enclosing R 2 2(14), R 2 2(12), R 2 2(10) and R 4 4(4) loops. The title compound complements the known ortho-rhom-bic form of natural (homochiral) chloramphenicol [Acharya et al. (1979 ▸). Acta Cryst. B35, 1360-1363], which crystallizes in space group C2221. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from H⋯O/O⋯H (39.4%), H⋯H (21.7%), H⋯C/C⋯H (15.5%) and Cl⋯C/C⋯Cl (8.3%) inter-actions.
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