Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Therapy00:59

Gene Therapy

28.2K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
28.2K
Gene Therapy00:59

Gene Therapy

4.9K
4.9K
What is Genetic Engineering?00:49

What is Genetic Engineering?

81.9K
Overview
81.9K
Teeth01:15

Teeth

2.4K
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
2.4K
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

17.7K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
17.7K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.5K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ahead of her time: The multidimensional impact of Marie Ussing Nylen.

Oral diseases·2022
Same author

Foreword.

Journal of the National Cancer Institute. Monographs·2019
Same author

Preface.

Oral diseases·2018
Same author

Professor Crispian Scully.

Oral diseases·2017
Same author

Gene Therapy of Salivary Diseases.

Methods in molecular biology (Clifton, N.J.)·2016
Same author

Outcomes From the NIH Clinical Research Training Program: A Mentored Research Experience to Enhance Career Development of Clinician-Scientists.

Academic medicine : journal of the Association of American Medical Colleges·2016

Related Experiment Video

Updated: Apr 17, 2026

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells
07:56

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells

Published on: November 16, 2018

7.3K

Gene therapy in dentistry: present and future.

Bruce J Baum

    American Journal of Dentistry
    |February 25, 2015
    PubMed
    Summary

    Gene therapy offers novel biological treatments for various clinical uses, including dentistry. This review explores its current applications and future implications for oral health over the next 25 years.

    Area of Science:

    • Biotechnology
    • Genetics
    • Oral Medicine

    Background:

    • Gene therapy utilizes biological treatments for diverse clinical applications.
    • This approach is under active investigation for its potential in various medical fields.
    • Several applications of gene therapy are relevant to the practice of dentistry.

    Purpose of the Study:

    • To provide background information on gene therapy as a novel biological treatment.
    • To assess the current general applications of gene therapy.
    • To review the specific applications of gene therapy within the oral cavity.
    • To project the implications of gene therapy in dentistry over the next 25 years.

    Main Methods:

    • Literature review of gene therapy research.

    More Related Videos

    Isolation of Epithelial Cells from Human Dental Follicle
    04:07

    Isolation of Epithelial Cells from Human Dental Follicle

    Published on: November 5, 2021

    3.4K
    Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
    11:02

    Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

    Published on: April 13, 2022

    4.3K

    Related Experiment Videos

    Last Updated: Apr 17, 2026

    Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells
    07:56

    Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells

    Published on: November 16, 2018

    7.3K
    Isolation of Epithelial Cells from Human Dental Follicle
    04:07

    Isolation of Epithelial Cells from Human Dental Follicle

    Published on: November 5, 2021

    3.4K
    Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
    11:02

    Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

    Published on: April 13, 2022

    4.3K
  • Analysis of current clinical applications.
  • Evaluation of studies related to oral and dental applications.
  • Forecasting future trends and potential impacts.

    • Main Results:

    • Gene therapy is a rapidly advancing field with broad clinical potential.
    • Existing research demonstrates feasibility for various therapeutic targets.
    • Specific applications in dentistry are emerging, though still in early stages.
    • Significant advancements are anticipated in the next 25 years.

    Conclusions:

    • Gene therapy holds considerable promise for transforming dental treatments.
    • Further research and clinical trials are necessary to realize its full potential in oral health.
    • The next quarter-century is expected to see substantial integration of gene therapy into dental practice.