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Updated: Apr 17, 2026
Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids
Published on: October 13, 2021
In-situ formation of growth-factor-loaded coacervate microparticle-embedded hydrogels for directing encapsulated stem
Oju Jeon1, David W Wolfson, Eben Alsberg
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Abstract:
The spontaneous formation of coacervate microdroplet-laden photo-crosslinked hydrogels derived from the simple mixing of oxidized, methacrylated alginate (OMA) and methacrylated gelatin (GelMA) enables simultaneous creation of drug-laden microdroplets and encapsulation of stem cells in photopolymerized coacervate hydrogels under physiological conditions. This can be utilized as a novel platform for in situ formation of localized, sustained bioactive molecule delivery to encapsulate stem cells for therapeutic applications.
