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Related Experiment Video

Updated: Apr 17, 2026

Simultaneous Isolation and Culture of Atrial Myocytes, Ventricular Myocytes, and Non-Myocytes from an Adult Mouse Heart
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[Changes of right atrial myoendocrine cells during hypertension and after arterial pressure decrease].

V F Maksimov, I M Korostyshevskaia, S A Kurganov

    Tsitologiia
    |February 26, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Atrial myoendocrine cells in hypertensive rats show increased natriuretic peptide release, which decreases with blood pressure reduction. This highlights the role of natriuretic peptides in regulating hemodynamics during hypertension.

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    Area of Science:

    • Cardiology
    • Endocrinology
    • Hypertension Research

    Background:

    • Atrial cardiomyocytes possess both contractile and endocrine functions, synthesizing and releasing natriuretic peptides.
    • Natriuretic peptides counteract the renin-angiotensin-aldosterone system, but their role in hypertension development remains debated.

    Purpose of the Study:

    • To evaluate the secretory activity of atrial myoendocrine cells in rats with inherited stress-induced arterial hypertension (ISIAH) using electron microscopy.
    • To investigate the impact of blood pressure reduction via losartan treatment on these cells.

    Main Methods:

    • Electron microscopy was employed to examine atrial myoendocrine cells.
    • Morphological analysis focused on secretory granule synthesis, accumulation, release, and cellular degradation.
    • Comparison was made between ISIAH rats, normotensive controls, and ISIAH rats treated with losartan.

    Main Results:

    • ISIAH rats (180 mm Hg) exhibited enhanced synthesis, accumulation, and release of natriuretic peptides compared to controls.
    • Losartan treatment (reducing pressure to 140 mm Hg) led to altered granule composition, reduced granule size and number, and diminished Golgi complexes.
    • Increased intracellular degradation of secretory stores and myocardial changes (hyperemia, edema) were observed post-losartan treatment.

    Conclusions:

    • Secretory activity of heart myoendocrine cells is significantly elevated in severe inherited hypertension.
    • This heightened activity directly correlates with arterial blood pressure levels.
    • Natriuretic peptides play an active role in hemodynamic regulation within cardiovascular pathology.