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Effect of selective blockade of α₂-adrenoceptor subtypes on cardiovascular system in rats
T L Zefirov1, L I Khisamieva, N I Ziyatdinova
1Department of Anatomy, Physiology and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia, zefirovtl@mail.ru.
Abstract:
Selective blockade of various α2-adrenoceptors exerts various effects on the cardiovascular system in rats. Blockade of α2A/D-adrenoceptors in experimental animals decelerates and then accelerates HR. Blockade of α2B-adrenoceptors produces a negative chronotropic effect; blockade of α2C-adrenoceptors has a positive chronotropic effect. Administration of selective blockers of α2A/D- and α2B-adrenoceptors causes hypotension, while selective blockade of α2C-adrenoceptors increases BP.
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