Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiological Barriers01:25

Physiological Barriers

5.8K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
5.8K
Overview of Anatomy and Physiology01:24

Overview of Anatomy and Physiology

41.1K
Human anatomy is the scientific study of the body's structures. Some of these structures are very small and can only be observed and analyzed with the assistance of a microscope. Other larger structures can readily be seen, manipulated, measured, and weighed. The word "anatomy" comes from a Greek root that means "to cut apart." Human anatomy was first studied by observing the body's exterior and the wounds of soldiers and other injuries. Later, physicians were allowed to...
41.1K
Introduction to Developmental Psychology01:27

Introduction to Developmental Psychology

2.3K
Developmental psychology explores the changes and continuities in human abilities throughout life, encompassing physical, cognitive, linguistic, and social dimensions. Human development is not restricted to growth, but includes aspects of decline, particularly in physical abilities as individuals age. Developmental psychologists seek to understand how people change as they age and how their mental and social skills evolve.Developmental MilestonesA key concept in developmental psychology is...
2.3K
Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

359
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
359
Clearance Models: Physiological Models01:09

Clearance Models: Physiological Models

431
Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
431
Information Processing Approach01:30

Information Processing Approach

839
The information-processing theory of cognitive development centers on fundamental mental processes, including attention, memory, and problem-solving skills. Researchers in this field examine how cognitive abilities, such as working memory, evolve and influence children's overall development. Studies indicate that children with stronger working memory tend to excel in reading comprehension, math, and problem-solving compared to peers with less efficient memory skills. Low working memory is...
839

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Interplay of Ontogeny and Phylogeny at the Transcriptome Level of the Tetrapod Heart.

Journal of experimental zoology. Part B, Molecular and developmental evolution·2025
Same author

Treatment adherence to olfactory training: a real-world observational study.

Rhinology·2023
Same author

Position paper on olfactory dysfunction: 2023

Rhinology·2023
Same author

Extreme weather conditions influence the frequency of epistaxis-related emergency room visits.

Rhinology·2022
Same author

Decreased angiogenesis as a possible pathomechanism in cervical degenerative myelopathy.

Scientific reports·2021
Same author

Association between olfactory function and quality of life in patients with olfactory disorders: a multicenter study in over 760 participants.

Rhinology·2021

Related Experiment Video

Updated: Apr 17, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

853

Challenges and opportunities in developmental integrative physiology.

C A Mueller1, J Eme1, W W Burggren2

  • 1Department of Biology, McMaster University, 1280 Main St. West, Hamilton, ON L8S 4K1, Canada.

Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
|February 26, 2015
PubMed
Summary

Environmental conditions during embryonic development impact adult health across species. Developmental plasticity offers survival advantages but can lead to long-term health issues like hypertension, highlighting research opportunities in comparative physiology.

Keywords:
Critical windowsDevelopmentEmbryoEpigeneticsFetusHeterochronyHeterokairyLeptinPerinatal

More Related Videos

Development of New Therapeutic Applications Using Microfluidics
08:56

Development of New Therapeutic Applications Using Microfluidics

Published on: October 1, 2007

5.7K
Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.7K

Related Experiment Videos

Last Updated: Apr 17, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

853
Development of New Therapeutic Applications Using Microfluidics
08:56

Development of New Therapeutic Applications Using Microfluidics

Published on: October 1, 2007

5.7K
Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.7K

Area of Science:

  • Comparative physiology
  • Developmental biology
  • Evolutionary biology

Background:

  • Adverse embryonic/fetal conditions can alter phenotypes in juveniles and adults.
  • Developmental plasticity is common across animal taxa.
  • Extreme perinatal growth in humans increases risk for adult diseases like hypertension.

Purpose of the Study:

  • To explore challenges and opportunities in comparative developmental physiology.
  • To present mechanisms, models, and experimental designs for studying animal phenotype development.
  • To discuss the implications of developmental plasticity and critical windows.

Main Methods:

  • Review of symposium findings from the 2014 American Physiological Society Intersociety Meeting.
  • Analysis of concepts including developmental plasticity (heterokairy), heterochrony, epigenetics, and critical windows.
  • Examination of human examples like catch-up growth and fetal programming.

Main Results:

  • Developmental plasticity can increase variation in developmental timing, providing raw material for evolution.
  • Critical windows represent vulnerable periods during development with lasting phenotypic and epigenetic alterations.
  • Altered development can lead to long-term health consequences, such as programmed hypertension.

Conclusions:

  • Comparative developmental physiology offers rewarding research avenues.
  • Grand challenges include integrating developmental timing, multiple stressors, epigenetic influences, and new models.
  • Understanding these processes is crucial for human health and development.