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Coexistence of NMDA and non-NMDA receptors on turtle horizontal cells revealed using isolated retina preparations
1Department of Physiology, Keio University School of Medicine, Tokyo, Japan.
Vision Research
|January 1, 1989
Abstract:
Effects of glutamate and its agonists on horizontal cells appeared diversely when studied in turtle eyecup preparations. Consistent results were obtained when the isolated retina preparations were used. Not only kainate and quisqualate but also N-methyl-D-aspartate (NMDA) caused a sustained depolarization and light-evoked responses were suppressed for as long as these agonists were superfused. A selective antagonist of NMDA, 2-amino-5-phosphonovalerate (APV), hyperpolarized horizontal cells and reduced their light-evoked responses. These results indicate the coexistence of NMDA and non-NMDA receptors on turtle horizontal cells.