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Updated: Apr 17, 2026
Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
Evaluation of intrabony defects treated with platelet-rich fibrin or autogenous bone graft: A comparative analysis
Ashish Mathur1, Vivek Kumar Bains1, Vivek Gupta2
1Department of Periodontology, Saraswati Dental College, Lucknow, Uttar Pradesh, India.
Objective:
The primary objective of this study was to compare clinically and radiographically the efficacy of autologous platelet rich fibrin (PRF) and autogenous bone graft (ABG) obtained using bone scrapper in the treatment of intrabony periodontal defects.
Materials And Methods:
Thirty-eight intrabony defects (IBDs) were treated with either open flap debridement (OFD) with PRF or OFD with ABG. Clinical parameters were recorded at baseline and 6 months postoperatively. The defect-fill and defect resolution at baseline and 6 months were calculated radiographically (intraoral periapical radiographs [IOPA] and orthopantomogram [OPG]).
Results:
Significant probing pocket depth (PPD) reduction, clinical attachment level (CAL) gain, defect fill and defect resolution at both PRF and ABG treated sites with OFD was observed. However, inter-group comparison was non-significant (P > 0.05). The bivariate correlation results revealed that any of the two radiographic techniques (IOPA and OPG) can be used for analysis of the regenerative therapy in IBDs.
Conclusion:
The use of either PRF or ABG were effective in the treatment of three wall IBDs with an uneventful healing of the sites.
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