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Updated: Apr 16, 2026

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies
Published on: July 4, 2017
Histological differences between various methods of hemiepiphysiodesis: is guided growth really different?
Ignacio Sanpera1, David Raluy-Collado, Guillem Frontera-Juan
1Departments of aPeadiatric Orthopaedics bMorbid Anatomy cResearch Unit, Hospital Universitari Son Espases dExperimental Laboratory, Hospital Son Llatzer, Palma de Mallorca, Spain.
Abstract:
Traditional systems of hemiepiphysiodesis are based on the application of asymmetrical compression to the physis to correct angular deformities. The guided growth method claims to act as a tension plate avoiding compression. The aim of this study was to confirm or refute this claim. Twenty-four White New Zealand rabbits were subjected to a proximal tibial hemiepiphysiodesis using either staples or a plate and two-screws method. Both methods succeeded in producing deformity. The initial existent histological differences between systems became less apparent after 6 weeks of hemiepiphysiodesis, when histological results were very similar. The findings suggest that the eight-plate system produces, like staples, compression of the physis, but the forces are applied more gradually.

