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Updated: Apr 16, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
Published on: May 3, 2018
Arterial stiffness and cardiac functions in patients with chronic venous disease
E Ozpelit1, M E Ozpelit, G Albayrak
1Department of Cardiology, Dokuz Eylul University, School of Medicine, Izmir, Turkey - ebru.ozpelit@gmail.com.
Insights
Chronic venous disease (CVD) may impact heart and arterial function. This study found subtle changes in heart structure and arterial stiffness in CVD patients, suggesting a potential subclinical disease state.
Area of Science:
- Cardiovascular Medicine
- Vascular Biology
Background:
- The venous system connects directly to the heart and arterial circulation.
- The impact of chronic venous disease (CVD) on cardiac and arterial function is not well understood.
Purpose of the Study:
- To investigate global left and right heart function in patients with CVD.
- To assess arterial stiffness parameters in individuals with CVD.
Main Methods:
- Echocardiography with Doppler and tissue Doppler (TD) parameters were used to evaluate left and right ventricular function.
- Applanation tonometry assessed arterial stiffness.
- Study included 48 patients with stage C4-C6 CVD and 39 healthy controls.
Main Results:
- Patients with CVD showed slightly increased left atrial area and interventricular septum thickness.
- Right ventricular (RV) tissue Doppler systolic velocity and TAPSE were elevated in CVD patients.
- Arterial stiffness parameters, including central aortic pressure and pulse wave velocity, were slightly higher in the CVD group.
Conclusions:
- CVD may be linked to a subclinical disease state affecting both the arterial system and the heart.
- Further research is necessary to confirm this association and elucidate underlying mechanisms.
Aim:
Although the venous system is in direct continuity with the heart and the arterial system, it is not known whether chronic venous disease (CVD) has any impact on either of these. The aims of this study were to investigate the global functions of the left and right heart, and also arterial stiffness parameters in patients with CVD.
Methods:
Forty-eight patients with primary stage C4-C6 CVD were enrolled into the study. The control group consisted of 39 age/sex and Body Mass Index matched healthy volunteers. All of the patients underwent detailed echocardiographic examination with further focus on Doppler and tissue Doppler (TD) parameters of the left and right ventricle. Arterial stiffness was evaluated via applanation tonometry in each patient.
Results:
The left atrial area (LAA) and interventricular septum thickness were slightly increased in patients with CVD. Regarding Doppler and tissue Doppler measurements of the LV, all of the parameters were similar among the groups, while RV tissue Doppler systolic velocity and TAPSE were higher in patients with CVD. Among the arterial stiffness parameters, central aortic pressure, augmentation index, and pulse wave velocity were slightly higher in patients with CVD.
Conclusion:
The results of this study indicated that CVD may be associated with a subclinical disease state in the arterial system and also in the heart. Further studies are needed to confirm this association and to describe the possible mechanisms.
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