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Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI
Published on: November 22, 2016
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Relative and absolute structure of phomolide C
Atsushi Ito1, Hyato Maeda, Akio Tonouchi
1a The United Graduate School of Agricultural Science , Iwate University , Morioka , Japan.
Bioscience, Biotechnology, and Biochemistry
|March 3, 2015
Summary
Phomolide C, a compound from Diaporthe fungus, had its full 3D structure determined. Detailed Nuclear Magnetic Resonance (NMR) and Electronic Circular Dichroism (ECD) studies revealed its stereochemistry.
Area of Science:
- Natural Product Chemistry
- Mycology
- Spectroscopy
Background:
- Phomolide C was previously isolated from the fungus Diaporthe sp.
- Only the planar structure of Phomolide C was known before this study.
- The fungus was discovered in the Shirakami mountainous area.
Purpose of the Study:
- To elucidate the complete three-dimensional structure of Phomolide C.
- To determine the relative and absolute configuration of Phomolide C.
- To contribute to the understanding of natural products from fungal sources.
Main Methods:
- Isolation of Phomolide C from Diaporthe sp.
- Detailed Nuclear Magnetic Resonance (NMR) spectroscopic analysis.
- Electronic Circular Dichroism (ECD) studies.
Main Results:
- The complete relative configuration of Phomolide C was established.
- The absolute configuration of Phomolide C was determined.
- This study provides the first detailed stereochemical analysis of Phomolide C.
Conclusions:
- The full structure of Phomolide C, including its stereochemistry, has been elucidated.
- NMR and ECD are powerful tools for determining the configuration of natural products.
- This research expands the knowledge of Phomolide C's chemical properties.
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