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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
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The expression of twist in differentiated thyroid carcinomas
Cristina Mariana Calangiu1, C Mărgăritescu2, Daniela Cernea3
1Phd Student, Pathology Department, University of Medicine and Pharmacy of Craiova.
Current Health Sciences Journal
|March 3, 2015
Summary
Twist protein is overexpressed in differentiated thyroid carcinomas, correlating with invasive and metastatic tumor characteristics. This finding suggests Twist
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Differentiated thyroid carcinoma (DTC) generally has a favorable prognosis.
- Some DTC patients face risks of recurrence and metastasis.
Purpose of the Study:
- To investigate the role of Twist expression in differentiated thyroid carcinomas.
- To correlate Twist expression with clinicopathological parameters.
Main Methods:
- Analysis of 43 differentiated thyroid carcinoma cases.
- Immunohistochemical assessment of Twist expression.
- Correlation of Twist immunoexpression with tumor type, subtype, stage, and metastasis.
Main Results:
- Twist immunoreaction was detected in 79% of cases.
- Twist expression levels (low or high) did not differ by tumor type or subtype.
- Twist immunoexpression was significantly higher in invasive tumors and those with metastasis.
- Overexpression of Twist is associated with an invasive and metastatic immunophenotype in DTC.
Conclusions:
- Twist overexpression is linked to advanced tumor characteristics in differentiated thyroid carcinoma.
- Twist may serve as a potential biomarker for invasive and metastatic potential in DTC.
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